About Us

The Earle group's research is focused on the application and development of quasioptical techniques to improve the sensitivity of very high frequency (95—250GHz) EPR spectrometers for the study of funda­mental processes in biological and physical-inorganic systems. Continuing this work and its application to systems of biophysical in­terest is of key importance to obtain in­sights into basic questions of structure, dynamics and biological function.

We are particularly interested in the development of experimental, analytical and numerical tools for the evaluation and improvement of novel quasioptical structures for the study of aqueous in vitro samples with future applications to in vivo samples.

Parameter estimation is a particularly important problem in simultaneous multifrequency ESR spectral analysis. We are currenlty developing techniques drawing on insights from statistical geometry, maximum entropy methods, and analogues of thermodynamic systems to obtain minimally-biased parameters that can inform models of structure and dynamics

The analysis of magnetic resonance (NMR and ESR) spectra, particularly multi-frequency and time-domain experiments, is an important area of research as ever-more sophistiated experi­ntal techniques are introduced. We are developing computational methds, based on path-integral techniques, to perform cal­culations that will supplement more traditional methods based on eigenfunction expansions.

Recent work has focussed on developing a Hamiltonian Graphical User Interface (GUI) that has the potential for greatly simplifying the often tedious manipulations required for computing the matrix elements of Hamiltonians describing systems where many orbital angular momenta and spins are coupled.

As a colleague of mine once drolly observed:

"If we knew what we were doing, it wouldn't be research."